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AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: pre-clinical evidence for its association with chronic lymphocytic leukemia treatments.

机译：AMD3100破坏了慢性淋巴细胞白血病细胞与间质基质或护士样细胞微环境之间的串扰：临床前证据表明其与慢性淋巴细胞白血病治疗相关。

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Interactions with the microenvironment, such as bone marrow mesenchymal stromal cells and nurse-like cells, protect chronic lymphocytic leukemia cells from spontaneous and drug-induced apoptosis. This protection is partially mediated by the chemokine SDF-1α (CXCL12) and its receptor CXCR4 (CD184) present on the chronic lymphocytic leukemia cell surface.

机译：与微环境的相互作用，例如骨髓间充质基质细胞和护士样细胞，可以保护慢性淋巴细胞性白血病细胞免于自发和药物诱导的凋亡。这种保护作用部分由慢性淋巴细胞性白血病细胞表面上存在的趋化因子SDF-1α（CXCL12）及其受体CXCR4（CD184）介导。

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Stamatopoulos, Basile; Meuleman, Nathalie; De Bruyn, Cécile; Pieters, Karlien; Mineur, Philippe; Le Roy, Christine; Saint-Georges, Stéphane; Varin-Blank, Nadine; Cymbalista, Florence; Bron, Dominique; Lagneaux, Laurence;
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年度 2012
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专利

1. SYK Inhibition Disrupts the Cross-Talk Between B-Cell Activation Factor (BAFF) and B-Cell Receptor (BCR) and Thereby Antagonizes Mcl-1 in Chronic Lymphocytic Leukemia (CLL) B-Cells [J] . Paiva Cody, Rowland Taylor, Danilova Olga, Blood: The Journal of the American Society of Hematology . 2016,第22期

机译：SYK抑制破坏了B细胞活化因子（BAFF）和B细胞受体（BCR）之间的交叉对话，从而拮抗了慢性淋巴细胞白血病（CLL）B细胞中的Mcl-1。
2. Mixed-species RNAseq analysis of human lymphoma cells adhering to mouse stromal cells identifies a core gene set that is also differentially expressed in the lymph node microenvironment of mantle cell lymphoma and chronic lymphocytic leukemia patients [J] . Gustav Arvidsson, Johan Henriksson, Birgitta Sander, Haematologica . 2018,第4期

机译：粘附于小鼠基质细胞的人类淋巴瘤细胞的混合物种RNAseq分析确定了核心基因组，该基因组在套细胞淋巴瘤和慢性淋巴细胞性白血病患者的淋巴结微环境中也有差异表达
3. Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: a potential new therapeutic target. [J] . Hegde GV, Peterson KJ, Emanuel K, Molecular cancer research: MCR . 2008,第12期

机译：在基质细胞微环境中，刺猬诱导的B细胞慢性淋巴细胞性白血病细胞的存活：潜在的新治疗靶点。
4. Detection of de novo IGHV mutations by ultra-deep sequencing from in vitro activated B-cell chronic lymphocytic leukemia cells: Evidence for activation-induced deaminase function [C] . Chu C.C., Patten P.E.M., MacCarthy T, International Congress of Immunology. . 2014

机译：通过来自体外活化B细胞慢性淋巴细胞白血病细胞超深序的De Novo IghV突变检测：活化诱导的脱氨酶功能的证据
5. Molecular and cellular determinants of lymph node microenvironment-induced immunosuppression in chronic lymphocytic leukemia. [D] . Cutucache, Christine E. 2012

机译：慢性淋巴细胞白血病中淋巴结微环境诱导的免疫抑制的分子和细胞决定因素。
6. AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: pre-clinical evidence for its association with chronic lymphocytic leukemia treatments [O] . Basile Stamatopoulos, Nathalie Meuleman, Cécile De Bruyn, 2012

机译：AMD3100破坏了慢性淋巴细胞白血病细胞与间质基质或护士样细胞为基础的微环境之间的串扰：其与慢性淋巴细胞白血病治疗相关的临床前证据
7. AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: pre-clinical evidence for its association with chronic lymphocytic leukemia treatments [O] . Stamatopoulos, Basile, Meuleman, Nathalie, De Bruyn, Cécile, 2011

机译：AMD3100破坏了慢性淋巴细胞性白血病细胞与间充质基质或护士样细胞微环境之间的串扰：其与慢性淋巴细胞性白血病治疗相关的临床前证据

AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: pre-clinical evidence for its association with chronic lymphocytic leukemia treatments.

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